Welcome to the homepage of the Institute for Developmental Immunology (IDI) at the Biocenter of the Medical University of Innsbruck. The IDI is currently headed by Prof. Andreas Villunger, PhD, who was appointed as a head of this unit in 2007 as junior professor and is now full professor for Developmental Immunology at MUI.


The Institute is organized in four research groups, run by head Andreas Villunger and assistant/associate professors Jan Wiegers, Joel Riley, Verena Labi and Sebastian Herzog. Please click the logo to learn more about the respective groups!

With their coworkers, IDI investigators explore basic mechanisms of immune cell development and differentiation with a focus on microRNAs and steroid hormones. In addition, we are interested in studying general principles of cellular transformation, focusing on the role of BCL2-regulated cell death and the p53 signalling network as barrier against malignant disease.

All group leaders are involved in training undergraduate as well as graduate students of different life-science disciplines, including biochemistry, biology as well as molecular and human medicine. If you are interested in research training opportunities at different levels (summer students, BSc, MSc, or MD/PhD), or have any teaching related questions, please contact Claudia in administration to organize an appointment with your group leader of interest (Claudia.Ram@i-med.ac.at).

Recent News


Together with the Finotello group from our partner University in Innsbruck, the Labi, Riley and Villunger groups will receive 1,5 Mio. Euros from the Austrian Science Fund (FWF) for their BEAT IT consortium.

Induction of apoptosis is at the core of current cancer therapies. Despite the wealth of knowledge on apoptosis, we do lack understanding of how transforming cells escape extinction. BEAT IT seeks to understand the cell death dynamics that unfolds upon selective introduction of genomic perturbations in immune cells. Further, BEAT IT will provide proof of concept that this knowledge can be used to fight blood cancer and promote healthy ageing.

Apply now - we are looking for motivated PhD students and Post Docs to complete our BEAT IT team!

In our newly funded FWF Project, we aim to understand the relevance of the caspase-2-PIDDosome and its key-substrate, MDM2, in natural polyploidization, we will exploit cell biology, RNA-sequencing and mouse genetics to study centrosome-dependence of PIDDosome activation, transcriptional programs initiated by the caspase-2-PIDDosome and the consequences of impaired PIDDosome function for natural polyploidization, terminal differentiation and cellular behavior.

Congratulations to Ilaria Dorigatti and Nadine Kinz for receiving the “Stipendium der Allgemeinen Hochschulstipendienstiftung für Studierende der Universität Innsbruck und der Medizinischen Universität Innsbruck“! Each year, three young researchers with an excellent academic performance are selected by the “Hochschulstipendienstiftung” and honored for their scientific achievements. The award is intended to support the young scientists in their early career. Keep up the great work!

Congrats! Sarah Spöck received the 1st SZABO SCANDIC Immunis Sponsorship for young scientists. Focusing on B cells, Sarah’s project will elucidate how the epigenetic TET proteins prevent autoimmunity or immunodeficiency while promoting protective antibody-mediated immunity. We are looking forward to hearing more about this exciting project!

We are happy to announce that Joel Riley from the Beatson Institute for Cancer Research in Glasgow decided to join the team as a new Group Leader and Tenure Track Professor. Joel will start by the end of the year and will head the "Cell Death & Inflammation" Lab. Welcome, Joel!

After assessing the role of the PIDDosome in liver development (PMID: 31983631) and hepatocellular carcinoma (PMID: 33225610), a team involving former PhD student Valentina, Felix, Institute head Andreas Villunger and hepatologist Thomas Reiberger from Vienna has now compiled a Review Article that summarizes the current knowledge about polyploidy control in the healthy as well as the diseased liver.