Publications

1. Schoeler K, Jakic B, Heppke J, Soratroi C, Aufschnaiter A, Hermann-Kleiter N, Villunger A, Labi V. CHK1 dosage in germinal center B cells controls humoral immunity. Cell Death Differ. 2019 Mar 20 doi: 10.1038/s41418-019-0318-5 IF: 8.339

 

2. Labi V, Schoeler K, Melamed D. miR17-92 in lymphocyte development and lymphopoiesis. Cancer Lett. 2019 Apr 1;446:73-80. doi: 10.1016/j.canlet.2018.12.020 IF: 6.429

 

3. Bemhanmou D, Labi V, Getahun A, Bencherit E, Dowery R, Rajewsky K, Cambier JC, Melamed D. The c-Myc/miR17-92/PTEN Axis Tunes PI3K Activity to Control Expression of Recombination Activating Gene in Early B Cell Development. Front Immunol. 2018 Nov 22;9:2715. doi: 10.3389/fimmu.2018.02715 IF: 6.429

 

4. Tuzlak S, Haschka M, Mokina A, Ruelicke T, Cory S, Labi V, Villunger A. Differential effects of Vav-promoter-driven overexpression of BCLX and BFL1 on lymphocyte survival and lymphomagenesis. FEBS Journal. 2018 Apr;285(8):1403-18. doi: 10.1111/febs.14426 IF: 4.530

 

5. Schuler F, Weiss JG, Lindner SE, Lohmüller M, Herzog S, Spiegl SF, Menke P, Geley S, Labi V, Villunger A. Checkpoint kinase 1 is essential for normal B cell development and lymphomagenesis. Nat Commun. 2017 Nov 22;8(1):1697. doi: 10.1038/s41467-017-01850-4 IF: 12.124

 

6. Kollek M, Voigt G, Molnar C, Murad F, Bertele D, Krombholz CF, Bohler S, Labi V, Schiller S, Kunze M, Geley S, Niemeyer CM, Garcia-Saez A, Erlacher M. Transient apoptosis inhibition in donor stem cells improves hematopoietic stem cell transplantation. Journal of Experimental Medicine. 2017 Oct 2;214(10):2967-83. doi:10.1084/jem.20161721 IF: 11.991

 

7. *** Benhamou D, *** Labi V, Novak R, Dai I, Shafir-Alon S, Arnold R, Rajewsky K, Melamed D. A c-Myc/miR-17~92/Pten axis controls PI3K-mediated positive and negative selection in B cell development and reconstitutes CD19 deficiency. Cell Reports. 2016 Jul 12;16(2):419-31. doi: 10.1016/j.celrep.2016.05.084

+++ These authors contributed equally to this work. IF: 8.282

 

8. Derudder E, Herzog S, Labi V, Yasuda T, Köchert K, Janz M, Villunger A, Schmidt-Supprian M, Rajewsky K. Canonical NF-kB signaling is uniquely required for the long-term persistence of functional mature B cells. Proc Natl Acad Sci U S A. 2016 May 3;113(18):5065-70. doi: 10.1073/pnas.1604529113 IF: 9.661

 

9. *** Orlanski S, *** Labi V, Reizel Y, Spiro A, Lichtenstein M, Levin-Klein R, Koralov SB, Skversky Y, Rajewsky K, Cedar H, Bergman Y. Tissue-specific DNA demethylation is required for proper B-cell differentiation and function. Proc Natl Acad Sci U S A. 2016 May 3;113(18):5018-23. doi: 10.1073/pnas.1604365113 +++ These authors contributed equally to this work. IF: 9.661

 

10. Woess C, Tuzlak S, Labi V, Drach M, Bertele D, Schneider P, Villunger A. Combined loss of the BH3-only proteins Bim and Bmf restores B-cell development and function in TACI-Ig transgenic mice. Cell Death Differ. 2015 Sep;22(9):1477-88. doi: 10.1038/cdd.2015.8 IF: 8.339

 

11. Labi V, Erlacher M. How cell death shapes cancer. Cell Death Dis. 2015 Mar 5. doi: 10.1038/cddis.2015.20 IF: 5.965

 

12. Labi V, Woess C, Tuzlak S, Erlacher M, Bouillet P, Strasser A, Tzankov A, Villunger A. Deregulated cell death and lymphocyte homeostasis cause premature lethality in mice lacking the BH3-only proteins Bim and Bmf. Blood. 2014 Apr 24;123(17):2652-62. doi: 10.1182/blood-2013-11-537217 IF: 13.164

 

13. Schweingruber N, Fischer HJ, Fischer L, van den Brandt J, Karabinskaya A, Labi V, Villunger A, Kretzschmar B, Huppke P, Simons M, Tuckermann JP, Flügel A, Lühder F, Reichardt HM. Chemokine-mediated redirection of T cells constitutes a critical mechanism of glucocorticoid therapy in autoimmune CNS responses. Acta Neuropathol. 2014 May;127(5):713-29. doi: 10.1007/s00401-014-1248-4 IF: 12.213

 

14. Wensveen FM, Geest CR, Libregts SF, Derks IA, Ekert PG, Labi V, Villunger A, Nolte MA, Eldering E. BH3-only protein Noxa contributes to apoptotic control of stress-erythropoiesis. Apoptosis. 2013 Nov;18(11):1306-18. doi: 10.1007/s10495-013-0890-y IF: 3.833

 

15. Labi V, Bertele D, Woess C, Tischner D, Bock FJ, Schwemmers S, Pahl HL, Geley S, Kunze M, Niemeyer CM, Villunger A, Erlacher M. Hematopoietic stem cell survival and transplantation efficacy is limited by the BH3-only proteins Bim and Bmf. EMBO Mol Med. 2013 Jan;5(1):122-36. doi: 10.1002/emmm.201201235 IF: 9.249

 

16. Baumgartner F, Woess C, Pedit V, Tzankov A, Labi V, Villunger A. Minor cell-death defects but reduced tumor latency in mice lacking the BH3-only proteins Bad and Bmf. Oncogene. 2013 Jan 31;32(5):621-30. doi: 10.1038/onc.2012.78 IF: 7.519

 

17. Manzl C, Peintner L, Krumschnabel G, Bock F, Labi V, Drach M, Newbold A, Johnstone R, Villunger A. PIDDosome-independent tumor suppression by Caspase-2. Cell Death Differ. 2012 Oct;19(10):1722-32. doi: 10.1038/cdd.2012.54 IF: 8.339

 

18. Villunger A, Labi V, Bouillet P, Adams J, Strasser A. Can the analysis of BH3-only protein knockout mice clarify the issue of direct versus indirect” activation of Bax and Bak? Cell Death Differ. 2011 Oct;18(10):1545-6. doi: 10.1038/cdd.2011.100 IF: 8.339

 

19. Karlberg M, Ekoff M, Labi V, Strasser A, Huang D, Nilsson G. Pro-apoptotic Bax is the major and Bak an auxiliary effector in cytokine deprivation-induced mast cell apoptosis. Cell Death Dis. 2010. May 13;1:e43. doi: 10.1038/cddis.2010.20 IF: 5.965

 

20. Melum E, Franke A, Schramm C, Weismüller TJ, Gotthardt DN, Offner FA, Juran BD, Laerdahl JK, Labi V, et. al. Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci. Nat Genet. 2011 Jan;43(1):17-9. doi: 10.1038/ng.728 IF: 27.125

 

21. Labi V, Villunger A. PUMA-mediated tumor suppression: A tale of two stories. Cell Cycle 2010 Nov1;9(21):4269-75. PMID: 20980816 IF: 3.952

 

22. Labi V, Erlacher M, Krumschnabel G, Manzl C, Tzankov A, Pinon J, Egle A, Villunger A. Apoptosis triggered by acute DNA-damage promotes lymphoma formation. Genes & Development. 2010 Aug1; 24(15):1602-07. doi: 10.1101/gad IF: 9.413

 

23. Santidrián AF, González-Gironès DM, Iglesias-Serret D, Coll-Mulet L, Cosialls AM, de Frias M, Campàs C, González-Barca E, Alonso E, Labi V, Viollet B, Benito A, Pons G, Villunger A, Gil J. AICAR induces apoptosis independently of AMPK and p53 through up-regulation of the BH3-only proteins BIM and NOXA in chronic lymphocytic leukemia cells. Blood. 2010 Oct21;116(16):3023-32. doi: 10.1182/blood-2010-05-283960 IF: 13.164

 

24. Frenzel A, Labi V, Chmelewskij W, Ploner C, Geley S, Fiegl H, Tzankov A, Villunger A. Suppression of B cell lymphomagenesis by the BH3-only proteins Bmf and Bad. Blood. 2010 Feb4; 115(5):995-1005. doi: 10.1182/blood-2009-03-212670 IF: 13.164

 

25. Pinon JD, Labi V, Egle A and Villunger A. Bim and Bmf in tissue homeostasis and malignant disease. Oncogene. 2008 Dec; 27 Suppl 1:S41-52. doi: 10.1038/onc.2009.42 IF: 6.854

 

26. Huntington ND, Labi V, Cumano A, Vieira P, Strasser A, Villunger A, Di Santo JP, Alves NL. Loss of the pro-apoptotic Bcl2-family member Bim sustains B lymphopoiesis in the absence of IL-7. Int. Immunol. 2009 Jun; 21(6): 715-25. doi: 10.1093/intimm/dxp043 IF: 3.403

 

27. Manzl C, Krumschnabel G, Bock F, Sohm B, Labi V, Baumgartner F, Logette E, Tschopp J and Villunger A. Caspase-2 activation in the absence of PIDDosome formation. Journal of Cell Biology 2009 Apr20; 185(2): 291 – 303. doi: 10.1083/jcb.200811105 IF: 8.784

 

28. Nordigarden A, Kraft M, Eliasson P, Labi V, Lam EW, Villunger A and Jönsson JI. BH3-only protein Bim more critical than Puma in tyrosine kinase inhibitor-induced apoptosis of human leukemic cells and transduced hematopoietic progenitors carrying oncogenic FLT3. Blood 2009 Mar 5;113(10):2302-11. doi: 10.1182/blood-2008-07-167023 IF: 13.164

 

29. Hermann-Kleiter N, Gruber T, Lutz-Nicoladoni C, Thuille N, Fresser F, Labi V, Schiefermeier N, Warnecke M, Huber L, Villunger A, Eichele G, Kaminski S and Baier G. The nuclear orphan receptor NR2F6 suppresses lymphocyte activation and T helper 17- dependent autoimmunity. Immunity 2008 Aug; 29(2): 205-16. doi: 10.1016/j.immuni.2008.06.008 IF: 19.734

 

30. Labi V, Grespi F, Baumgartner F and Villunger A. Targeting the Bcl-2-regulated apoptosis pathway by BH3 mimetics: a breakthrough in anticancer therapy? Cell Death Differ. 2008 Jun;15(6):977-87. doi: 10.1038/cdd.2008.37 IF: 8.339

 

31. Labi V, Erlacher M, Kiessling S, Manzl C, Frenzel A, O’Reilly L, Strasser A, Villunger A. Loss of the BH3-only protein Bmf impairs B cell homeostasis and accelerates gamma irradiation-induced thymic lymphoma development. Journal of Experimental Medicine 2008 Mar 17; 205(3):641-55. doi: 10.1084/jem.20071658 IF: 11.991

 

32. Erlacher M, Labi V, Manzl C, Böck G, Tzankov A, Häcker G, Michalak E, Strasser A, Villunger A. Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis induction. Journal of Experimental Medicine 2006 Dec 25; 203(13):2939-51. PMID: 17178918 IF: 11.991

 

33. Bauer A, Villunger A, Labi V, Fischer SF, Wagner H, Schmid RM, Häcker G. The NF-kappaB regulator Bcl-3 and the BH3-only proteins Bim and Puma control the death of activated T cells. Proc Natl Acad Sci U S A. 2006 Jul 18;103(29):10979-84. PMID: 16832056 IF: 9.661

 

34. Labi V, Erlacher M, Kiessling S, Villunger A. BH3-only proteins in cell death initiation, malignant disease and anticancer therapy. Cell Death Differ. 2006 Aug;13(8):1325-38. PMID: 16645634 IF: 8.339

 

35. Erlacher M, Michalak EM, Kelly PN, Labi V, Niederegger H, Coultas L, Adams JM, Strasser A, Villunger A. The BH3-only proteins PUMA/bbc3 and Bim are rate-limiting for γ-radiation and glucocorticoid induced apoptosis of lymphoid cells in vivo. Blood. 2005 Dec 15;106(13):4131-8. PMID: 16118324 IF: 13.164

 

36. Heiser D, Labi V, Erlacher M, Villunger A. The Bcl-2 protein family and its role in the development of neoplastic disease. Experimental Gerontology 2004 Aug; 39 (8): 1125-35. PMID: 15288687 IF: 1.88