2024
Braun VZ, Karbon G, Schuler F, Schapfl MA, Weiss JG, Petermann PY, Spierings DCJ, Tijhuis AE, Foijer F, Labi V, Villunger A. Extra centrosomes delay DNA damage-driven tumorigenesis. Sci Adv. 2024
Mar 29;10(13):eadk0564. doi: 10.1126/sciadv.adk0564.
Epub 2024 Mar 29.
PMID: 38552015
Lambrecht R, Rudolf F, Ückert AK, Sladky VC, Phan TS, Jansen J, Naim S, Kaufmann T, Keogh A, Kirschnek S, Mangerich A, Stengel F, Leist M, Villunger A, Brunner T. Non-canonical BIM-regulated
energy metabolism determines drug-induced liver necrosis. Cell Death Differ. 2024 Jan;31(1):119-131. doi: 10.1038/s41418-023-01245-7. Epub 2023 Nov 24.
PMID: 38001256
2023
Garcia-Carpio I, Braun VZ, Weiler ES, Leone M, Niñerola S, Barco A, Fava LL, Villunger A. Extra centrosomes induce PIDD1-mediated inflammation and immunosurveillance. EMBO J. 2023 Oct
16;42(20):e113510. doi: 10.15252/embj.2023113510. Epub 2023 Aug 2.
PMID: 37530438
Fang J, de Bruin A, Villunger A, Schiffelers R, Lei Z, Sluijter JPG. Cellular polyploidy in organ homeostasis and regeneration. Protein Cell. 2023 Aug 1;14(8):560-578. doi: 10.1093/procel/pwac064.
PMID: 37526344
X
Vitale I, [...], Galluzzi L. Apoptotic cell death in disease - Current understanding of the NCCD 2023. Cell Death Differ. 2023 May;30(5):1097-1154. doi:
10.1038/s41418-023-01153-w. Epub 2023 Apr 26.
PMID: 37100955
Meyer-Heemsoth L, Mitschke K, Bier J, Schütz K, Villunger A, Legler TJ, Weber MS, Lühder F, Reichardt HM. T Cell Energy Metabolism Is a Target of Glucocorticoids in Mice, Healthy Humans, and MS
Patients. Cells. 2023 Jan 30;12(3):450. doi: 10.3390/cells12030450.
PMID: 36766792
Herzog C, Vavourakis CD, Barrett JE, Karbon G, Villunger A, Wang J, Sundström K, Dillner J, Widschwendter M. HPV-induced host epigenetic reprogramming is lost upon progression to high-grade
cervical intraepithelial neoplasia. Int J Cancer. 2023 Jun 1;152(11):2321-2330. doi: 10.1002/ijc.34477. Epub 2023 Mar 8.
PMID: 36810770
2022
Flores-Romero H, Hohorst L, John M, Albert MC, King LE, Beckmann L, Szabo T, Hertlein V, Luo X, Villunger A, Frenzel LP, Kashkar H, Garcia-Saez AJ. BCL-2-family protein tBID can act as a BAX-like
effector of apoptosis. EMBO J. 2022 Dec 17;41(2):e108690. doi: 10.15252/embj.2021108690. Epub 2021 Dec 21.
PMID: 34931711
Weiss JG, Gallob F, Rieder P, Villunger A. Apoptosis as a Barrier against CIN and Aneuploidy. Cancers (Basel). 2022 Dec 21;15(1):30. doi: 10.3390/cancers15010030.
PMID: 36612027
Hutter K, Rülicke T, Szabo TG, Andersen L, Villunger A, Herzog S. The miR-15a/16-1 and miR-15b/16-2 clusters regulate early B cell development by limiting IL-7 receptor expression. Front Immunol.
2022 Aug 25;13:967914. doi: 10.3389/fimmu.2022.967914. eCollection 2022.
PMID: 36110849
Kim JY, Wang LQ, Sladky VC, Oh TG, Liu J, Trinh K, Eichin F, Downes M, Hosseini M, Jacotot ED, Evans RM, Villunger A, Karin M. PIDDosome-SCAP crosstalk controls high-fructose-diet-dependent
transition from simple steatosis to steatohepatitis. Cell Metab. 2022 Oct 4;34(10):1548-1560.e6. doi: 10.1016/j.cmet.2022.08.005. Epub 2022 Aug 29.
PMID: 36041455
Rocamora-Reverte L, Villunger A, Wiegers GJ. Cell-Specific Immune Regulation by Glucocorticoids in Murine Models of Infection and Inflammation. Cell-Specific Immune Regulation by Glucocorticoids
in Murine Models of Infection and Inflammation. Cells. 2022 Jul 6;11(14):2126. doi: 10.3390/cells11142126.
PMID: 35883569
Lohmüller M, Roeck BF, Szabo TG, Schapfl MA, Pegka F, Herzog S, Villunger A, Schuler F. The SKP2-p27 axis defines susceptibility to cell death upon CHK1 inhibition. Mol Oncol. 2022
Aug;16(15):2771-2787. doi: 10.1002/1878-0261.13264. Epub 2022 Jul 7.
PMID: 35673965
Hutter K, Lindner SE, Kurschat C, Rülicke T, Villunger A, Herzog S. The miR-26 family regulates early B cell development and transformation. Life Sci Alliance. 2022 Apr 22;5(8):e202101303. doi:
10.26508/lsa.202101303.
PMID: 3545973
Weiler ES, Szabo TG, Garcia-Carpio I, Villunger A. PIDD1 in cell cycle control, sterile inflammation and cell death. Biochem Soc Trans. 2022 Apr 29;50(2):813-824. doi: 10.1042/BST20211186.
PMID: 35343572
Flores-Romero H, Hohorst L, John M, Albert MC, King LE, Beckmann L, Szabo T, Hertlein V, Luo X, Villunger A, Frenzel LP, Kashkar H,
Garcia-Saez AJ. BCL-2-family protein tBID can act as a BAX-like effector of apoptosis. EMBO J. 2022 Dec 17;41(2):e108690. doi: 10.15252/embj.2021108690. Epub 2021 Dec 21.
PMID: 34931711
Karbon G, Haschka MD, Hackl H, Soratroi C, Rocamora-Reverte L, Parson W, Fiegl H, Villunger A. The BH3-only protein NOXA serves as an independent predictor of breast cancer patient survival and defines susceptibility to
microtubule targeting agents. Cell Death Dis. 2021 Dec 13;12(12):1151. doi: 10.1038/s41419-021-04415-y.
PMID: 34903710
Rizzotto D, Englmaier L, Villunger A. At a Crossroads to
Cancer: How p53-Induced Cell Fate Decisions Secure Genome Integrity. Int J Mol Sci. 2021
Oct 8;22(19):10883. doi: 10.3390/ijms221910883.
PMID: 34639222
Sladky VC, Eichin F, Reiberger T, Villunger A. Polyploidy control in hepatic health and disease.
J Hepatol. 2021 Nov;75(5):1177-1191. doi: 10.1016/j.jhep.2021.06.030. Epub 2021 Jul 3.
PMID: 34228992
Sheikh TI, Vasli N, Pastore S, Kharizi K, Harripaul R, Fattahi Z, Pande S, Naeem F, Hussain A, Mir A, Islam O, Girisha KM, Irfan M, Ayub M, Schwarzer C,
Najmabadi H, Shukla A, Sladky VC, Braun VZ, Garcia-Carpio I, Villunger A, Vincent JB. Biallelic mutations in the death domain of PIDD1
impair caspase-2 activation and are associated with intellectual disability. Transl Psychiatry. 2021 Jan 5;11(1):1. doi:
10.1038/s41398-020-01158-w.
PMID: 33414379
Sladky VC, Eichin F, Reiberger T, Villunger A. Polyploidy control in hepatic health and disease. J Hepatol. 2021 Nov;75(5):1177-1191.
doi: 10.1016/j.jhep.2021.06.030. Epub 2021 Jul 3.
PMID: 34228992.
Rizzotto D, Villunger A. P53 clears aneuploid cells by entosis. Cell Death Differ. 2021 Feb;28(2):818-820.
doi: 10.1038/s41418-020-00659-x. Epub 2020 Nov 4.
PMID: 33149274; PMCID: PMC7862590.
Rizzotto D, Englmaier L, Villunger A. At a Crossroads to Cancer: How p53-Induced Cell Fate Decisions Secure Genome Integrity. Int J
Mol Sci. 2021 Oct 8;22(19):10883. doi: 10.3390/ijms221910883.
PMID: 34639222; PMCID: PMC8509445.
Flores-Romero H, Hohorst L, John M, Albert MC, King LE, Beckmann L, Szabo T, Hertlein V, Luo X, Villunger A, Frenzel LP, Kashkar H,
Garcia-Saez AJ. BCL-2-family protein tBID can act as a BAX-like effector of apoptosis. EMBO J. 2022 Dec 17;41(2):e108690.
doi: 10.15252/embj.2021108690. Epub 2021 Dec 21.
PMID: 34931711; PMCID: PMC8762556.
You H, Pellegrini M, Tsuchihara K, Yamamoto K, Hacker G, Erlacher M, Villunger A, Mak TW.
Correction: FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal. J Exp Med. 2021 Feb 1;218(2):jem.2006035301132021c.
doi: 10.1084/jem.2006035301132021c. Erratum for: J Exp Med. 2006 Jul
10;203(7):1657-63
PMID: 33471042; PMCID: PMC7821124.
Karbon G, Haschka MD, Hackl H, Soratroi C, Rocamora-Reverte L, Parson W, Fiegl H, Villunger A. The BH3-only protein NOXA serves as an
independent predictor of breast cancer patient survival and defines susceptibility to microtubule targeting agents. Cell Death Dis. 2021 Dec 13;12(12):1151. doi: 10.1038/s41419-021-04415-y
PMID: 34903710; PMCID: PMC8668920.
2020
Burigotto M, Mattivi A, Migliorati D, Magnani G, Valentini C, Roccuzzo M, Offterdinger M, Pizzato M, Schmidt A, Villunger A, Maffini S, Fava LL.
Centriolar distal appendages activate the centrosome-PIDDosome-p53 signalling axis via ANKRD26.
EMBO J. 2020 Dec 22:e104844. doi: 10.15252/embj.2020104844.
PMID: 33350486
Sladky VC, Knapp K, Szabo TG, Braun VZ, Bongiovanni L, van den Bos H, Spierings DC, Westendorp B, Curinha A, Stojakovic T, Scharnagl H, Timelthaler G,
Tsuchia K, Pinter M, Semmler G, Foijer F, de Bruin A, Reiberger T, Rohr-Udilova N, Villunger A.
PIDDosome-induced p53-dependent ploidy restriction facilitates hepatocarcinogenesis
EMBO Rep. 2020 Nov 23;21(12):e50893. doi: 10.15252/embr.202050893.
PMID: 33225610
Rizzotto D, Villunger A.P53 clears aneuploid cells by entosis.
Cell Death Differ. 2020 Nov 4. doi: 10.1038/s41418-020-00659-x.
PMID: 33149274
Hutter K, Rülicke T, Drach M, Andersen L, Villunger A, Herzog S.
Differential roles of miR-15a/16-1 and miR-497/195 clusters in immune cell development and homeostasis.
FEBS J. 2020 Jul 23. doi: 10.1111/febs.15493.
PMID: 32705746
Hutter K, Lohmüller M, Jukic A, Eichin F, Avci S, Labi V, Szabo TG, Hoser SM, Hüttenhofer A, Villunger A, Herzog S.
SAFB2 Enables the Processing of Suboptimal Stem-Loop Structures in Clustered Primary miRNA Transcripts.
Mol Cell. 2020 Jun 4;78(5):876-889.e6. doi: 10.1016/j.molcel.2020.05.011.
PMID: 32502422
Sladky VC, Villunger A.
Uncovering the PIDDosome and caspase-2 as regulators of organogenesis and cellular differentiation.
Cell Death Differ. 2020 May 15. doi: 10.1038/s41418-020-0556-6.
PMID: 32415279
Peña-Blanco A, Haschka MD, Jenner A, Zuleger T, Proikas-Cezanne T, Villunger A, García-Sáez AJ.
Drp1 modulates mitochondrial stress responses to mitotic arrest.
Cell Death Differ. 2020 Mar 19. doi: 10.1038/s41418-020-0527-y.
PMID: 32203171
Haschka MD, Karbon G, Soratroi C, O'Neill KL, Luo X, Villunger A.
MARCH5-dependent degradation of MCL1/NOXA complexes defines susceptibility to antimitotic drug treatment.
Cell Death Differ. 2020 Feb 3. doi: 10.1038/s41418-020-0503-6.
PMID: 32015503
Sladky VC, Knapp K, Soratroi C, Heppke J, Eichin F, Rocamora-Reverte L, Szabo TG, Bongiovanni L, Westendorp B, Moreno E, van Liere EA, Bakker B, Spierings DCJ, Wardenaar R, Pereyra D, Starlinger
P, Schultze S, Trauner M, Stojakovic T, Scharnagl H, Fava LL, Foijer F, de Bruin A, Villunger A.
E2F-Family Members Engage the PIDDosome to Limit Hepatocyte Ploidy in Liver Development and Regeneration.
Dev Cell. 2020 Feb 10;52(3):335-349.e7. doi: 10.1016/j.devcel.2019.12.016. Epub 2020 Jan 23.
PMID: 31983631
Connolly P, Garcia-Carpio I, Villunger A.
Cell-Cycle Cross Talk with Caspases and Their Substrates.
Cold Spring Harb Perspect Biol. 2020 Jun 1;12(6):a036475. doi: 10.1101/cshperspect.a036475.
PMID: 3172767
Singh PK, Roukounakis A, Weber A, Das KK, Sohm B, Villunger A, Garcia-Saez AJ, Häcker G.
Dynein light chain binding determines complex formation and posttranslational stability of the Bcl-2 family members Bmf and Bim.
Cell Death Differ. 2020 Feb;27(2):434-450. doi: 10.1038/s41418-019-0365-y. Epub 2019 Jun 12.
PMID: 31189926
2019
Schuler F, Afreen S, Manzl C, Häcker G, Erlacher M, Villunger A.
Checkpoint kinase 1 is essential for fetal and adult hematopoiesis.
EMBO Rep. 2019 Jun 17. pii: e47026. doi: 10.15252/embr.201847026.
PMID: 31208967
Schoeler K, Aufschnaiter A, Messner S, Derudder E, Herzog S, Villunger A, Rajewsky K, Labi V.
TET enzymes control antibody production and shape the mutational landscape in germinal centre B cells.
FEBS J. 2019 May 23. doi: 10.1111/febs.14934.
PMID: 31120187
Rocamora-Reverte L, Tuzlak S, von Raffay L, Tisch M, Fiegl H, Drach M, Reichardt HM, Villunger A, Tischner D, Wiegers GJ.
Glucocorticoid Receptor-Deficient Foxp3+ Regulatory T Cells Fail to Control Experimental Inflammatory Bowel Disease.
Front Immunol. 2019 Mar 18;10:472. doi: 10.3389/fimmu.2019.00472. eCollection 2019.
PMID: 30936873
Schoeler K, Jakic B, Heppke J, Soratroi C, Aufschnaiter A, Hermann-Kleiter N, Villunger A, Labi V.
CHK1 dosage in germinal center B cells controls humoral immunity.
Cell Death Differ. 2019 Mar 20. doi: 10.1038/s41418-019-0318-5. [Epub ahead of print]
PMID: 30894677
Liccardi G, Ramos Garcia L, Tenev T, Annibaldi A, Legrand AJ, Robertson D, Feltham R, Anderton H, Darding M, Peltzer N, Dannappel M, Schünke H, Fava LL, Haschka MD, Glatter T, Nesvizhskii A,
Schmidt A, Harris PA, Bertin J, Gough PJ, Villunger A, Silke J, Pasparakis M, Bianchi K, Meier P.
RIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and Inflammation.
Mol Cell. 2019 Feb 7;73(3):413-428.e7. doi: 10.1016/j.molcel.2018.11.010. Epub 2018 Dec 28.
PMID: 30598363
2018
Bellutti F, Tigan AS, Nebenfuehr S, Dolezal M, Zojer M, Grausenburger R, Hartenberger S, Kollmann S, Doma E, Prchal-Murphy M, Uras IZ, Höllein A, Neuberg DS, Ebert BL, Ringler A, Mueller AC,
Loizou JI, Hinds PW, Vogl C, Heller G, Kubicek S, Zuber J, Malumbres M, Farlik M, Villunger A, Kollmann K, Sexl V.
CDK6 Antagonizes p53-Induced Responses during Tumorigenesis.
Cancer Discov. 2018 Jul;8(7):884-897. doi: 10.1158/2159-8290.CD-17-0912. Epub 2018 Jun 13.
PMID: 29899063
Tuzlak S, Haschka MD, Mokina AM, Rülicke T, Cory S, Labi V, Villunger A.
Differential effects of Vav-promoter-driven overexpression of BCLX and BFL1 on lymphocyte survival and B cell lymphomagenesis.
FEBS J. 2018 Apr;285(8):1403-1418. doi: 10.1111/febs.14426. Epub 2018 Mar 24.
PMID: 29498802
Haschka M, Karbon G, Fava LL, Villunger A.
Perturbing mitosis for anti-cancer therapy: is cell death the only answer?
EMBO Rep. 2018 Mar;19(3). pii: e45440. doi: 10.15252/embr.201745440. Epub 2018 Feb 19. Review.
PMID: 29459486
Rabachini T, Fernandez-Marrero Y, Montani M, Loforese G, Sladky V, He Z, Bachmann D, Wicki S, Villunger A, Stroka D, Kaufmann T.
BOK promotes chemical-induced hepatocarcinogenesis in mice.
Cell Death Differ. 2018 Mar;25(4):706-718. doi: 10.1038/s41418-017-0008-0. Epub 2017 Dec 11.
PMID: 29229991
2017
Schuler F, Weiss JG, Lindner SE, Lohmüller M, Herzog S, Spiegl SF, Menke P, Geley S, Labi V, Villunger A.
Checkpoint kinase 1 is essential for normal B cell development and lymphomagenesis.
Nat Commun. 2017 Nov 22;8(1):1697. doi:10.1038/s41467-017-01850-4.
PMID: 29167438
Müller L, Hainberger D, Stolz V, Hamminger P, Hassan H, Preglej T, Boucheron N, Sakaguchi S, Wiegers GJ, Villunger A, Auwerx J, Ellmeier W.
The corepressor NCOR1 regulates the survival of single-positive thymocytes.
Sci Rep. 2017 Nov 21;7(1):15928. doi: 10.1038/s41598-017-15918-0.
PMID: 29162920
Sladky V, Schuler F, Fava LL, Villunger A.
The resurrection of the PIDDosome - emerging roles in the DNA-damage response and centrosome surveillance.
J Cell Sci. 2017 Nov 15;130(22):3779-3787. doi: 10.1242/jcs.203448. Review.
PMID: 29142064
Ottina E, Peperzak V, Schoeler K, Carrington E, Sgonc R, Pellegrini M, Preston S, Herold MJ, Strasser A, Villunger A.
DNA-binding of the Tet-transactivator curtails antigen-induced lymphocyte activation in mice.
Nat Commun. 2017 Oct 18;8(1):1028. doi: 10.1038/s41467-017-01022-4.
PMID: 29044097
Gulen MF, Koch U, Haag SM, Schuler F, Apetoh L, Villunger A, Radtke F, Ablasser A.
Signalling strength determines proapoptotic functions of STING.
Nat Commun. 2017 Sep 5;8(1):427. doi: 10.1038/s41467-017-00573-w.
PMID: 28874664
Rocamora-Reverte L, Reichardt HM, Villunger A, Wiegers G.
T-cell autonomous death induced by regeneration of inert glucocorticoid metabolites.
Cell Death Dis. 2017 Jul 20;8(7):e2948. doi: 10.1038/cddis.2017.344.
PMID: 28726773
Lindner SE, Lohmüller M, Kotkamp B, Schuler F, Knust Z, Villunger A, Herzog S.
The miR-15 family reinforces the transition from proliferation to differentiation in pre-B cells.
EMBO Rep. 2017 Sep;18(9):1604-1617. doi:10.15252/embr.201643735. Epub 2017 Jul 13.
PMID: 28705801
Ebner F, Sedlyarov V, Tasciyan S, Ivin M, Kratochvill F, Gratz N, Kenner L, Villunger A, Sixt M, Kovarik P.
The RNA-binding protein tristetraprolin schedules apoptosis of pathogen-engaged neutrophils during bacterial infection.
J Clin Invest. 2017 Jun 1;127(6):2051-2065. doi: 10.1172/JCI80631. Epub 2017 May 15.
PMID: 28504646
Haschka MD, Villunger A.
There is something about BOK we just don't get yet.
FEBS J. 2017 Mar;284(5):708-710. doi: 10.1111/febs.14031.
PMID: 28262002
Voráčová K, Hájek J, Mareš J, Urajová P, Kuzma M, Cheel J, Villunger A, Kapuscik A, Bally M, Novák P, Kabeláč M, Krumschnabel G, Lukeš M, Voloshko L, Kopecký J, Hrouzek P.
The cyanobacterial metabolite nocuolin a is a natural oxadiazine that triggers apoptosis in human cancer cells.
PLoS One. 2017 Mar 2;12(3):e0172850. doi: 10.1371/journal.pone.0172850. eCollection 2017.
PMID: 28253280
Fava LL, Schuler F, Sladky V, Haschka MD, Soratroi C, Eiterer L, Demetz E, Weiss G, Geley S, Nigg EA, Villunger A.
The PIDDosome activates p53 in response to supernumerary centrosomes.
Genes Dev. 2017 Jan 1;31(1):34-45. doi:10.1101/gad.289728.116.
PMID: 28130345
Tuzlak S, Schenk RL, Vasanthakumar A, Preston SP, Haschka MD, Zotos D, Kallies A, Strasser A, Villunger A, Herold MJ.
The BCL-2 pro-survival protein A1 is dispensable for T cell homeostasis on viral infection.
Cell Death Differ. 2017 Mar;24(3):523-533. doi: 10.1038/cdd.2016.155. Epub 2017 Jan 13.
PMID: 28085151
Schenk RL, Tuzlak S, Carrington EM, Zhan Y, Heinzel S, Teh CE, Gray DH, Tai L, Lew AM, Villunger A, Strasser A, Herold MJ.
Characterisation of mice lacking all functional isoforms of the pro-survival BCL-2 family member A1 reveals minor defects in the haematopoietic compartment.
Cell Death Differ. 2017 Mar;24(3):534-545. doi: 10.1038/cdd.2016.156. Epub 2017 Jan 13.
PMID: 28085150
