The Cell Death & Inflammation Lab

Current Team

Joel Riley, PhD (Group Leader)

Marlene Lochner (PhD student)

Julie Mathay (MSc student)

Christian Mayer (MSc student)

... You? We are recruiting a PhD student to work on our BEAT-IT project! Get in touch for more details.  

Current Funding

Work in the Cell Death & Inflammation lab is gratefully supported by

• FWF/Austrian Science Fund: Research Group "BEAT-IT" - BCL-2 Network Adaptations in B Cell Transformation
• TWF/Tyrolean Science Fund: Using advanced microscopy to understand cell death

Publications

2022

• Bock FJ & Riley JS. When cell death goes wrong: inflammatory outcomes of failed apoptosis and mitotic cell death. Cell Death Differ. Review.
• Riley JS & Bock FJ. Voices from beyond the grave: the impact of apoptosis on the microenvironment. Biochem Biophys Acta Mol Cell Res. Review.
• Zacharioudakis E, Agianian B, Kumar V MV, Biris N, Garner TP, Rabinovich-Nikitin I, Ouchida AT, Margulets V, Nordstrøm LU, Riley JS, Dolgalev I, Chen Y, Wittig AJH, Pekson R, Matthew C, Wei P, Tsirigos A, Tait SWG, Kirschenbaum LA, Kitsis RN & Gavathiotis E. Modulating mitofusins to control mitochondrial function and signalling. Nat Commun.
• Cao K*, Riley JS*, Heilig R, Montes-Gómez AE, Vringer E, Berthenet K, Cloix C, Elmasry Y, Spiller DG, Ichim G, Campbell KJ, Gilmore AP & Tait SWG. Mitochondrial dynamics regulate genome stability via control of caspase-dependent DNA damage. Dev Cell.

2021

• Rabas N, Palmer S, Mitchell L, Ishmael S, Goelke A, Riley JS, Tait SWG, Gammage P, Macpherson I & Norman JC. PINK1 drives production of mtDNA-containing extracellular vesicles to promote invasiveness. J Cell Biol.

2020

• Roberts JZ, Holohan C, Sessler T, Fox J, Crawford N, Riley JS, Khawaja H, Majkut J, Evergren E, Humphreys LM, Ferris J, Higgins C, Espona-Fiedler M, Moynagh P, McDade SS & Longley DB. The SCFSkp2 ubiquitin ligase complex modulates TRAIL-R2-induced apoptosis by regulating FLIP(L). Cell Death Differ. 
• Riley JS & Tait SWG. Mitochondrial DNA in inflammation and immunity. EMBO Rep. Review.  

2019

• Riley JS & Tait SWG. Mitochondria and pathogen immunity: from killer to firestarter. EMBO J. News & Views. 

2018

• Riley JS, Quarato G, Cloix C, Lopez J, O’Prey J, Pearson M, Chapman J, Sesaki H, Carlin LM, Passos JF, Wheeler AP, Ryan KM & Tait SW. Mitochondrial inner membrane permeabilisation enables mtDNA release during apoptosis. EMBO J.

2017

• Villa E, Proïcs E, Rubio-Patiño C, Obba S, Zunino B, Bossowski JP, Rozier JP, Chiche J, Mondragón L, Riley JS, Marchetti S, Verhoeyen E, Tait SWG, Ricci JE. Parkin-Independent Mitophagy Controls Chemotherapeutic Response in Cancer Cells. Cell Rep.

2016

• Riley JS & Tait SWG. Mechanisms of mitophagy: putting the powerhouse into the doghouse. Review.
• Lopez J, Bessou M*, Riley JS*, Giampazolias E, Todt F, Rochegüe T, Oberst A, Green DR, Edlich F, Ichim G & Tait SWG. Mito-priming as a method to engineer Bcl-2 addiction. Nat Commun.
• Riley JS, Malik A, Holohan C & Longley DB. DED or alive: assembly and regulation of the death effector domain complexes. Cell Death Dis. Review. 

2015

• Ichim G, Lopez J, Ahmed S, Muthalagu N, Giampazolias E, Delgado ME, Haller M, Riley JS, Mason SM, Athineos D, Parsons MJ, van de Kooij B, Bouchier-Hayes L, Chalmers AJ, Rooswinkel RW, Oberst A, Blyth K, Rehm M, Murphy DJ & Tait SWG. Limited mitochondrial permeabilization causes DNA damage and genomic instability in the absence of cell death. Mol Cell.

2014

• Schmid D, Fay F, Small DM, Jaworski J, Riley JS, Tegazzini D, Fenning C, Jones DS, Johnston PG, Longley DB & Scott CJ. Efficient drug delivery and induction of apoptosis in colorectal tumors using a death receptor 5-targeted nanomedicine. Mol Ther.
• Majkut J, Sgobba M, Holohan C, Crawford N, Logan AE, Kerr E, Redmond KL, Higgins CA, Riley JS, Stasik I, Fennell DA, Van Schaeybroeck S, Haider S, Johnston PG, Haigh D & Longley DB. Differential affinity of FLIP and procaspase 8 for FADD’s DED binding surfaces regulates DISC assembly. Nat Commun. 

2013

• Riley JS, Hutchinson R, McArt DG, Crawford N, Holohan C, Van Schaeybroeck S, Paul I, Johnston PG, Fennell DA, Gately K, O’Byrne K, Cummins R, Kay E, Hamilton P, Stasik I & Longley DB. Prognostic and therapeutic relevance of FLIP and procaspase-8 overexpression in non-small cell lung cancer. Cell Death Dis.

2012

• Kerr E, Holohan C, McLaughlin KM, Makjut J, Dolan S, Redmond K, Riley J, McLaughlin K, Stasik I, Crudden M, Van Schaeybroeck S, Fenning C, O’Connor R, Kiely P, Sgobba M, Haigh D, Johnston PG & Longley DB. Identification of an acetylation-dependant Ku70/FLIP complex that regulates FLIP expression and HDAC inhibitor-induced apoptosis. Cell Death Differ.