Publications

2016
Tuzlak S, Kaufmann T, Villunger A.

Interrogating the relevance of mitochondrial apoptosis for vertebrate development and postnatal tissue homeostasis.

Genes Dev. 2016 Oct 1;30(19):2133-2151. Review.

PMID: 27798841

Sochalska M, Schuler F, Weiss JG, Prchal-Murphy M, Sexl V, Villunger A.

MYC selects against reduced BCL2A1/A1 protein expression during B cell lymphomagenesis.

Oncogene. 2017 Apr;36(15):2066-2073. doi: 10.1038/onc.2016.362. Epub 2016 Oct 3.

PMID: 27694901

Brand A, Singer K, Koehl GE, Kolitzus M, Schoenhammer G, Thiel A, Matos C, Bruss C, Klobuch S, Peter K, Kastenberger M, Bogdan C, Schleicher U, Mackensen A, Ullrich E, Fichtner-Feigl S, Kesselring R, Mack M, Ritter U, Schmid M, Blank C, Dettmer K, Oefner PJ, Hoffmann P, Walenta S, Geissler EK, Pouyssegur J, Villunger A, Steven A, Seliger B, Schreml S, Haferkamp S, Kohl E, Karrer S, Berneburg M, Herr W, Mueller-Klieser W, Renner K, Kreutz M.

LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells.

Cell Metab. 2016 Nov 8;24(5):657-671. doi: 10.1016/j.cmet.2016.08.011. Epub 2016 Sep 15.

PMID: 27641098

Derudder E, Herzog S, Labi V, Yasuda T, Köchert K, Janz M, Villunger A, Schmidt-Supprian M, Rajewsky K.

Canonical NF-κB signaling is uniquely required for the long-term persistence of functional mature B cells.

Proc Natl Acad Sci U S A. 2016 May 3;113(18):5065-70. doi: 10.1073/pnas.1604529113. Epub 2016 Apr 20.

PMID: 27099294

García Sáez AJ, Villunger A.

MOMP in the absence of BH3-only proteins.

Genes Dev. 2016 Apr 15;30(8):878-80. doi: 10.1101/gad.281519.116.

PMID: 27083995

Sakamoto K, Wehde BL, Yoo KH, Kim T, Rajbhandari N, Shin HY, Triplett AA, Rädler PD, Schuler F, Villunger A, Kang K, Hennighausen L, Wagner KU.

Janus Kinase 1 Is Essential for Inflammatory Cytokine Signaling and Mammary Gland Remodeling.

Mol Cell Biol. 2016 May 16;36(11):1673-90. doi: 10.1128/MCB.00999-15. Print 2016 Jun 1.

PMID: 27044867

Bauer E, Schlederer M, Scheicher R, Horvath J, Aigner P, Schiefer AI, Kain R, Regele H, Hoermann G, Steiner G, Kenner L, Sexl V, Villunger A, Moriggl R, Stoiber D.

Cooperation of ETV6/RUNX1 and BCL2 enhances immunoglobulin production and accelerates glomerulonephritis in transgenic mice.

Oncotarget. 2016 Mar 15;7(11):12191-205. doi: 10.18632/oncotarget.7687.

PMID: 26919255

Podmirseg SR, Jäkel H, Ranches GD, Kullmann MK, Sohm B, Villunger A, Lindner H, Hengst L.

Caspases uncouple p27(Kip1) from cell cycle regulated degradation and abolish its ability to stimulate cell migration and invasion.

Oncogene. 2016 Sep 1;35(35):4580-90. doi: 10.1038/onc.2015.524. Epub 2016 Feb 1.

PMID: 26829051

Sochalska M, Ottina E, Tuzlak S, Herzog S, Herold M, Villunger A.

Conditional knockdown of BCL2A1 reveals rate-limiting roles in BCR-dependent B-cell survival.

Cell Death Differ. 2016 Apr;23(4):628-39. doi: 10.1038/cdd.2015.130. Epub 2015 Oct 9.

PMID: 26450454

2015
Hermann-Kleiter N, Klepsch V, Wallner S, Siegmund K, Klepsch S, Tuzlak S, Villunger A, Kaminski S, Pfeifhofer-Obermair C, Gruber T, Wolf D, Baier G.
The Nuclear Orphan Receptor NR2F6 Is a Central Checkpoint for Cancer Immune Surveillance.
Cell Rep. 2015 Sep 29;12(12):2072-85. doi: 10.1016/j.celrep.2015.08.035. Epub 2015 Sep 17.
PMID: 26387951

Fava LL, Rainer J, Haschka MD, Geley S, Villunger A.
Beclin 1 is dispensable for chromosome congression and proper outer kinetochore assembly.
EMBO Rep. 2015 Oct;16(10):1233-6. doi: 10.15252/embr.201540731. Epub 2015 Aug 20.
PMID: 26297610

Woess C, Drach M, Villunger A, Tappert R, Stalder R, Pallua JD.
Application of mid-infrared (MIR) microscopy imaging for discrimination between follicular hyperplasia and follicular lymphoma in transgenic mice.
Analyst. 2015 Sep 21;140(18):6363-72. doi: 10.1039/c5an01072a.
PMID: 26236782

Knackmuss U, Lindner SE, Aneichyk T, Kotkamp B, Knust Z, Villunger A, Herzog S.
MAP3K11 is a tumor suppressor targeted by the oncomiR miR-125b in early B cells.
Cell Death Differ. 2016 Feb;23(2):242-52. doi: 10.1038/cdd.2015.87. Epub 2015 Jul 3.
PMID: 26138442

Bock FJ, Tanzer MC, Haschka MD, Krumschnabel G, Sohm B, Goetsch K, Kofler R, Villunger A.
The p53 binding protein PDCD5 is not rate-limiting in DNA damage induced cell death.
Sci Rep. 2015 Jun 11;5:11268. doi: 10.1038/srep11268.
PMID: 26062895

Schuler F, Baumgartner F, Klepsch V, Chamson M, Müller-Holzner E, Watson CJ, Oh S, Hennighausen L, Tymoszuk P, Doppler W, Villunger A.
The BH3-only protein BIM contributes to late-stage involution in the mouse mammary gland.
Cell Death Differ. 2016 Jan;23(1):41-51. doi: 10.1038/cdd.2015.61. Epub 2015 Jun 5.
PMID: 26045049

Amort M, Nachbauer B, Tuzlak S, Kieser A, Schepers A, Villunger A, Polacek N.
Expression of the vault RNA protects cells from undergoing apoptosis.
Nat Commun. 2015 May 8;6:7030. doi: 10.1038/ncomms8030.
PMID: 25952297

Haschka MD, Soratroi C, Kirschnek S, Häcker G, Hilbe R, Geley S, Villunger A, Fava LL.
The NOXA-MCL1-BIM axis defines lifespan on extended mitotic arrest.
Nat Commun. 2015 Apr 29;6:6891. doi: 10.1038/ncomms7891.
PMID: 25922916

Peintner L, Dorstyn L, Kumar S, Aneichyk T, Villunger A, Manzl C.
The tumor-modulatory effects of Caspase-2 and Pidd1 do not require the scaffold protein Raidd.
Cell Death Differ. 2015 Nov;22(11):1803-11. doi: 10.1038/cdd.2015.31. Epub 2015 Apr 10.
PMID: 25857265

Woess C, Tuzlak S, Labi V, Drach M, Bertele D, Schneider P, Villunger A.
Combined loss of the BH3-only proteins Bim and Bmf restores B-cell development and function in TACI-Ig transgenic mice.
Cell Death Differ. 2015 Sep;22(9):1477-88. doi: 10.1038/cdd.2015.8. Epub 2015 Feb 20.
PMID: 25698446
Piatti P, Lim CY, Nat R, Villunger A, Geley S, Shue YT, Soratroi C, Moser M, Lusser A.
Embryonic stem cell differentiation requires full length Chd1.
Sci Rep. 2015 Jan 26;5:8007. doi: 10.1038/srep08007.
PMID: 25620209

Ottina E, Sochalska M, Sgonc R, Villunger A.
The BH3-only protein Bad is dispensable for TNF-mediated cell death.
Cell Death Dis. 2015 Jan 22;6:e1611. doi: 10.1038/cddis.2014.575.
PMID: 25611386

Sochalska M, Tuzlak S, Egle A, Villunger A.
Lessons from gain- and loss-of-function models of pro-survival Bcl2 family proteins: implications for targeted therapy.
FEBS J. 2015 Mar;282(5):834-849. doi: 10.1111/febs.13188. Epub 2015 Jan 23. Review.
PMID: 25559680

Ottina E, Lyberg K, Sochalska M, Villunger A, Nilsson GP.
Knockdown of the antiapoptotic Bcl-2 family member A1/Bfl-1 protects mice from anaphylaxis.
J Immunol. 2015 Feb 1;194(3):1316-22. doi: 10.4049/jimmunol.1400637. Epub 2014 Dec 29.
PMID: 25548219

Farrés J, Llacuna L, Martin-Caballero J, Martínez C, Lozano JJ, Ampurdanés C, López-Contreras AJ, Florensa L, Navarro J, Ottina E, Dantzer F, Schreiber V, Villunger A, Fernández-Capetillo O, Yélamos J.
PARP-2 sustains erythropoiesis in mice by limiting replicative stress in erythroid progenitors.
Cell Death Differ. 2015 Jul;22(7):1144-57. doi: 10.1038/cdd.2014.202. Epub 2014 Dec 12.
PMID: 25501596

2014
Fava LL, Villunger A.
Stop competing, start talking!
EMBO J. 2014 Sep 1;33(17):1849-51. doi: 10.15252/embj.201489466. Epub 2014 Jul 25.
PMID: 25063676

Andree M, Seeger JM, Schüll S, Coutelle O, Wagner-Stippich D, Wiegmann K, Wunderlich CM, Brinkmann K, Broxtermann P, Witt A, Fritsch M, Martinelli P, Bielig H, Lamkemeyer T, Rugarli EI, Kaufmann T, Sterner-Kock A, Wunderlich FT, Villunger A, Martins LM, Krönke M, Kufer TA, Utermöhlen O, Kashkar H.
BID-dependent release of mitochondrial SMAC dampens XIAP-mediated immunity against Shigella.
EMBO J. 2014 Oct 1;33(19):2171-87. doi: 10.15252/embj.201387244. Epub 2014 Jul 23.
PMID: 25056906

Labi V, Woess C, Tuzlak S, Erlacher M, Bouillet P, Strasser A, Tzankov A, Villunger A.
Deregulated cell death and lymphocyte homeostasis cause premature lethality in mice lacking the BH3-only proteins Bim and Bmf.
Blood. 2014 Apr 24;123(17):2652-62. doi: 10.1182/blood-2013-11-537217. Epub 2014 Mar 14.
PMID: 24632712

Schweingruber N, Fischer HJ, Fischer L, van den Brandt J, Karabinskaya A, Labi V, Villunger A, Kretzschmar B, Huppke P, Simons M, Tuckermann JP, Flügel A, Lühder F, Reichardt HM.
Chemokine-mediated redirection of T cells constitutes a critical mechanism of glucocorticoid therapy in autoimmune CNS responses.
Acta Neuropathol. 2014 May;127(5):713-29. doi: 10.1007/s00401-014-1248-4. Epub 2014 Feb 1.
PMID: 24488308

Manzl C, Fava LL, Krumschnabel G, Peintner L, Tanzer MC, Soratroi C, Bock FJ, Schuler F, Luef B, Geley S, Villunger A.
Death of p53-defective cells triggered by forced mitotic entry in the presence of DNA damage is not uniquely dependent on Caspase-2 or the PIDDosome.
Cell Death Dis. 2013 Dec 5;4:e942. doi: 10.1038/cddis.2013.470.
PMID: 24309929

Datta S, Parajuli N, Tymoszuk P, Ottina E, Parson W, Sgonc R, Villunger A, Doppler W.
Replenishment of the B cell compartment after doxorubicin-induced hematopoietic toxicity is facilitated by STAT1.
J Leukoc Biol. 2014 Jun;95(6):853-66. doi: 10.1189/jlb.0113053. Epub 2013 Dec 2.
PMID: 24295829

Lindner SE, Wissler M, Gründer A, Aumann K, Ottina E, Peintner L, Brauns-Schubert P, Preiss F, Herzog S, Borner C, Charvet C, Villunger A, Pahl HL, Maurer U.
Increased leukocyte survival and accelerated onset of lymphoma in the absence of MCL-1 S159-phosphorylation.
Oncogene. 2014 Oct 30;33(44):5221-4. doi: 10.1038/onc.2013.469. Epub 2013 Nov 11.
PMID: 24213575