Publications

2019

Schuler F, Afreen S, Manzl C, Häcker G, Erlacher M, Villunger A.

Checkpoint kinase 1 is essential for fetal and adult hematopoiesis.

EMBO Rep. 2019 Jun 17. pii: e47026. doi: 10.15252/embr.201847026.

PMID: 31208967

 

Singh PK, Roukounakis A, Weber A, Das KK, Sohm B, Villunger A, Garcia-Saez AJ, Häcker G.

Dynein light chain binding determines complex formation and posttranslational stability of the Bcl-2 family members Bmf and Bim.

Cell Death Differ. 2019 Jun 12. doi: 10.1038/s41418-019-0365-y.

PMID: 31189926

 

Schoeler K, Aufschnaiter A, Messner S, Derudder E, Herzog S, Villunger A, Rajewsky K, Labi V.

TET enzymes control antibody production and shape the mutational landscape in germinal centre B cells.

FEBS J. 2019 May 23. doi: 10.1111/febs.14934.

PMID: 31120187

 

Rocamora-Reverte L, Tuzlak S, von Raffay L, Tisch M, Fiegl H, Drach M, Reichardt HM, Villunger A, Tischner D, Wiegers GJ.

Glucocorticoid Receptor-Deficient Foxp3+ Regulatory T Cells Fail to Control Experimental Inflammatory Bowel Disease.

Front Immunol. 2019 Mar 18;10:472. doi: 10.3389/fimmu.2019.00472. eCollection 2019.

PMID: 30936873

 

Schoeler K, Jakic B, Heppke J, Soratroi C, Aufschnaiter A, Hermann-Kleiter N, Villunger A, Labi V.

CHK1 dosage in germinal center B cells controls humoral immunity.

Cell Death Differ. 2019 Mar 20. doi: 10.1038/s41418-019-0318-5. [Epub ahead of print]

PMID: 30894677

 

Liccardi G, Ramos Garcia L, Tenev T, Annibaldi A, Legrand AJ, Robertson D, Feltham R, Anderton H, Darding M, Peltzer N, Dannappel M, Schünke H, Fava LL, Haschka MD, Glatter T, Nesvizhskii A, Schmidt A, Harris PA, Bertin J, Gough PJ, Villunger A, Silke J, Pasparakis M, Bianchi K, Meier P.

RIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and Inflammation.

Mol Cell. 2019 Feb 7;73(3):413-428.e7. doi: 10.1016/j.molcel.2018.11.010. Epub 2018 Dec 28.

PMID: 30598363

 

2018
Bellutti F, Tigan AS, Nebenfuehr S, Dolezal M, Zojer M, Grausenburger R, Hartenberger S, Kollmann S, Doma E, Prchal-Murphy M, Uras IZ, Höllein A, Neuberg DS, Ebert BL, Ringler A, Mueller AC, Loizou JI, Hinds PW, Vogl C, Heller G, Kubicek S, Zuber J, Malumbres M, Farlik M, Villunger A, Kollmann K, Sexl V.
CDK6 Antagonizes p53-Induced Responses during Tumorigenesis.
Cancer Discov. 2018 Jul;8(7):884-897. doi: 10.1158/2159-8290.CD-17-0912. Epub 2018 Jun 13.
PMID: 29899063

Tuzlak S, Haschka MD, Mokina AM, Rülicke T, Cory S, Labi V, Villunger A.
Differential effects of Vav-promoter-driven overexpression of BCLX and BFL1 on lymphocyte survival and B cell lymphomagenesis.
FEBS J. 2018 Apr;285(8):1403-1418. doi: 10.1111/febs.14426. Epub 2018 Mar 24.
PMID: 29498802

Haschka M, Karbon G, Fava LL, Villunger A.
Perturbing mitosis for anti-cancer therapy: is cell death the only answer?
EMBO Rep. 2018 Mar;19(3). pii: e45440. doi: 10.15252/embr.201745440. Epub 2018 Feb 19. Review.
PMID: 29459486

Rabachini T, Fernandez-Marrero Y, Montani M, Loforese G, Sladky V, He Z, Bachmann D, Wicki S, Villunger A, Stroka D, Kaufmann T.
BOK promotes chemical-induced hepatocarcinogenesis in mice.
Cell Death Differ. 2018 Mar;25(4):706-718. doi: 10.1038/s41418-017-0008-0. Epub 2017 Dec 11.
PMID: 29229991

2017
Schuler F, Weiss JG, Lindner SE, Lohmüller M, Herzog S, Spiegl SF, Menke P, Geley S, Labi V, Villunger A.
Checkpoint kinase 1 is essential for normal B cell development and lymphomagenesis.
Nat Commun. 2017 Nov 22;8(1):1697. doi:10.1038/s41467-017-01850-4.
PMID: 29167438

Müller L, Hainberger D, Stolz V, Hamminger P, Hassan H, Preglej T, Boucheron N, Sakaguchi S, Wiegers GJ, Villunger A, Auwerx J, Ellmeier W.
The corepressor NCOR1 regulates the survival of single-positive thymocytes.
Sci Rep. 2017 Nov 21;7(1):15928. doi: 10.1038/s41598-017-15918-0.
PMID: 29162920

Sladky V, Schuler F, Fava LL, Villunger A.
The resurrection of the PIDDosome - emerging roles in the DNA-damage response and centrosome surveillance.
J Cell Sci. 2017 Nov 15;130(22):3779-3787. doi: 10.1242/jcs.203448. Review.
PMID: 29142064

Ottina E, Peperzak V, Schoeler K, Carrington E, Sgonc R, Pellegrini M, Preston S, Herold MJ, Strasser A, Villunger A.
DNA-binding of the Tet-transactivator curtails antigen-induced lymphocyte activation in mice.
Nat Commun. 2017 Oct 18;8(1):1028. doi: 10.1038/s41467-017-01022-4.
PMID: 29044097

Gulen MF, Koch U, Haag SM, Schuler F, Apetoh L, Villunger A, Radtke F, Ablasser A.
Signalling strength determines proapoptotic functions of STING.
Nat Commun. 2017 Sep 5;8(1):427. doi: 10.1038/s41467-017-00573-w.
PMID: 28874664

Rocamora-Reverte L, Reichardt HM, Villunger A, Wiegers G.
T-cell autonomous death induced by regeneration of inert glucocorticoid metabolites.
Cell Death Dis. 2017 Jul 20;8(7):e2948. doi: 10.1038/cddis.2017.344.
PMID: 28726773

Lindner SE, Lohmüller M, Kotkamp B, Schuler F, Knust Z, Villunger A, Herzog S.
The miR-15 family reinforces the transition from proliferation to differentiation in pre-B cells.
EMBO Rep. 2017 Sep;18(9):1604-1617. doi:10.15252/embr.201643735. Epub 2017 Jul 13.
PMID: 28705801

Ebner F, Sedlyarov V, Tasciyan S, Ivin M, Kratochvill F, Gratz N, Kenner L, Villunger A, Sixt M, Kovarik P.
The RNA-binding protein tristetraprolin schedules apoptosis of pathogen-engaged neutrophils during bacterial infection.
J Clin Invest. 2017 Jun 1;127(6):2051-2065. doi: 10.1172/JCI80631. Epub 2017 May 15.
PMID: 28504646

Haschka MD, Villunger A.
There is something about BOK we just don't get yet.
FEBS J. 2017 Mar;284(5):708-710. doi: 10.1111/febs.14031.
PMID: 28262002

Voráčová K, Hájek J, Mareš J, Urajová P, Kuzma M, Cheel J, Villunger A, Kapuscik A, Bally M, Novák P, Kabeláč M, Krumschnabel G, Lukeš M, Voloshko L, Kopecký J, Hrouzek P.
The cyanobacterial metabolite nocuolin a is a natural oxadiazine that triggers apoptosis in human cancer cells.
PLoS One. 2017 Mar 2;12(3):e0172850. doi: 10.1371/journal.pone.0172850. eCollection 2017.
PMID: 28253280

Fava LL, Schuler F, Sladky V, Haschka MD, Soratroi C, Eiterer L, Demetz E, Weiss G, Geley S, Nigg EA, Villunger A.
The PIDDosome activates p53 in response to supernumerary centrosomes.
Genes Dev. 2017 Jan 1;31(1):34-45. doi:10.1101/gad.289728.116.
PMID: 28130345

Tuzlak S, Schenk RL, Vasanthakumar A, Preston SP, Haschka MD, Zotos D, Kallies A, Strasser A, Villunger A, Herold MJ.
The BCL-2 pro-survival protein A1 is dispensable for T cell homeostasis on viral infection.
Cell Death Differ. 2017 Mar;24(3):523-533. doi: 10.1038/cdd.2016.155. Epub 2017 Jan 13.
PMID: 28085151

Schenk RL, Tuzlak S, Carrington EM, Zhan Y, Heinzel S, Teh CE, Gray DH, Tai L, Lew AM, Villunger A, Strasser A, Herold MJ.
Characterisation of mice lacking all functional isoforms of the pro-survival BCL-2 family member A1 reveals minor defects in the haematopoietic compartment.
Cell Death Differ. 2017 Mar;24(3):534-545. doi: 10.1038/cdd.2016.156. Epub 2017 Jan 13.
PMID: 28085150

2016
Tuzlak S, Kaufmann T, Villunger A.

Interrogating the relevance of mitochondrial apoptosis for vertebrate development and postnatal tissue homeostasis.

Genes Dev. 2016 Oct 1;30(19):2133-2151. Review.

PMID: 27798841

 

Sochalska M, Schuler F, Weiss JG, Prchal-Murphy M, Sexl V, Villunger A.

MYC selects against reduced BCL2A1/A1 protein expression during B cell lymphomagenesis.

Oncogene. 2017 Apr;36(15):2066-2073. doi: 10.1038/onc.2016.362. Epub 2016 Oct 3.

PMID: 27694901

 

Brand A, Singer K, Koehl GE, Kolitzus M, Schoenhammer G, Thiel A, Matos C, Bruss C, Klobuch S, Peter K, Kastenberger M, Bogdan C, Schleicher U, Mackensen A, Ullrich E, Fichtner-Feigl S, Kesselring R, Mack M, Ritter U, Schmid M, Blank C, Dettmer K, Oefner PJ, Hoffmann P, Walenta S, Geissler EK, Pouyssegur J, Villunger A, Steven A, Seliger B, Schreml S, Haferkamp S, Kohl E, Karrer S, Berneburg M, Herr W, Mueller-Klieser W, Renner K, Kreutz M.

LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells.

Cell Metab. 2016 Nov 8;24(5):657-671. doi: 10.1016/j.cmet.2016.08.011. Epub 2016 Sep 15.

PMID: 27641098

 

Derudder E, Herzog S, Labi V, Yasuda T, Köchert K, Janz M, Villunger A, Schmidt-Supprian M, Rajewsky K.

Canonical NF-κB signaling is uniquely required for the long-term persistence of functional mature B cells.

Proc Natl Acad Sci U S A. 2016 May 3;113(18):5065-70. doi: 10.1073/pnas.1604529113. Epub 2016 Apr 20.

PMID: 27099294

 

García Sáez AJ, Villunger A.

MOMP in the absence of BH3-only proteins.

Genes Dev. 2016 Apr 15;30(8):878-80. doi: 10.1101/gad.281519.116.

PMID: 27083995

 

Sakamoto K, Wehde BL, Yoo KH, Kim T, Rajbhandari N, Shin HY, Triplett AA, Rädler PD, Schuler F, Villunger A, Kang K, Hennighausen L, Wagner KU.

Janus Kinase 1 Is Essential for Inflammatory Cytokine Signaling and Mammary Gland Remodeling.

Mol Cell Biol. 2016 May 16;36(11):1673-90. doi: 10.1128/MCB.00999-15. Print 2016 Jun 1.

PMID: 27044867

 

Bauer E, Schlederer M, Scheicher R, Horvath J, Aigner P, Schiefer AI, Kain R, Regele H, Hoermann G, Steiner G, Kenner L, Sexl V, Villunger A, Moriggl R, Stoiber D.

Cooperation of ETV6/RUNX1 and BCL2 enhances immunoglobulin production and accelerates glomerulonephritis in transgenic mice.

Oncotarget. 2016 Mar 15;7(11):12191-205. doi: 10.18632/oncotarget.7687.

PMID: 26919255

 

Podmirseg SR, Jäkel H, Ranches GD, Kullmann MK, Sohm B, Villunger A, Lindner H, Hengst L.

Caspases uncouple p27(Kip1) from cell cycle regulated degradation and abolish its ability to stimulate cell migration and invasion.

Oncogene. 2016 Sep 1;35(35):4580-90. doi: 10.1038/onc.2015.524. Epub 2016 Feb 1.

PMID: 26829051

 

Sochalska M, Ottina E, Tuzlak S, Herzog S, Herold M, Villunger A.

Conditional knockdown of BCL2A1 reveals rate-limiting roles in BCR-dependent B-cell survival.

Cell Death Differ. 2016 Apr;23(4):628-39. doi: 10.1038/cdd.2015.130. Epub 2015 Oct 9.

PMID: 26450454

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